I’m using the Syphon Client example composition found in the quartz composer plugin package to bring video into Serato via Resolume. When active, you can periodically see the video go black for a split second, as opposed to playing smoothly. However it works fine when previewing in quartz composer.
My Macbook Pro specs are:
2.2GHz quad-core Intel Core i7 processor
16 GB RAM (2 x Corsair 8GB DDR3 1333MHz)
AMD Radeon HD 6750M graphics processor with 512MB of GDDR5 memory